Cenforce 150 mg should be taken approximately 30 minutes to 1 hour before sexual activity. It can be taken with or without food, although taking it with a high-fat meal may delay its onset of action. Sildenafil citrate typically begins to work within 30 to 60 minutes after ingestion and remains effective for up to 4 to 6 hours. However, individual response may vary, and some men may experience effects for a shorter or longer duration.